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This Week in Cell: Feb 16, 2012

In a recent Cell Reports article, a team led by investigators at the San Raffaele Institute in Milan, Italy, shows that endogenous microRNAs, like miR-511-3p, "may operate to establish thresholds for inflammatory cell activation in tumors." In its paper, team says that "miR-511-3p modulates genetic programs of tumor-associated macrophages," and identifies direct targets of the miRNA. "Enhancing miR-511-3p activity in TAMs [tumor-associated macrophages] may represent a therapeutic strategy to reprogram them from a protumoral to an antitumoral phenotype," the authors write.

Elsewhere in Cell Reports, Cold Spring Harbor Laboratory's Adrian Krainer and his colleagues show that "MYC and SRSF1 are significantly coexpressed in lung and breast cancers," and that the former directly targets the latter. The team also reports that "SRSF1 knockdown reduces MYC-mediated transformation," and hence its oncogenic activity.

Over in Molecular Cell, an international team led by investigators at Spain's University of Córdoba shows that in Arabidopsis, the "DNA phosphatase ZDP removes the blocking 3' phosphate, allowing subsequent DNA polymerization and ligation steps needed to complete the repair reactions" downstream of ROS1. As such, the Córdoba-led team says ZDP functions as part of an active DNA demethylation pathway in the model plant.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.