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In a paper published online in advance in Cell this week, investigators at the University of Vienna and the Hebrew University-Hadassah Medical School show that the toxin MazF "cleaves at ACA sites at or closely upstream of the AUG start codon of some specific mRNAs and thereby generates leaderless mRNAs." The team also reports on a subpopulation of ribosomes that it says "selectively translates the described leaderless mRNAs both in vivo and in vitro."

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Nature News writes that viral genomic surveillance in the US faces systemic issues.

President Joe Biden is seeking an increase in federal spending, including higher budgets for the National Institutes of Health and Centers for Disease Control and Prevention.

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