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New York University School of Medicine's Evgeny Nudler et al. link RNA polymerase backtracking to genome instability in E. coli in Cell this week. In its paper, the NYU team shows that "co-directional collisions between backtracked RNAP [RNA polymerase] and replisome lead to DSBs [double-strand breaks]" in the bacterium. It also shows that "active ribosomes preserve genome integrity" by preventing such backtracking.

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Russia says its candidate SARS-CoV-2 vaccine has a very high efficacy rate in an initial analysis of clinical trial data, according to the Financial Times.

Wired reports on a microbial analysis of sketches drawn by Leonardo DaVinci.

A new survey explores coronavirus vaccine hesitancy among Black and Latino individuals, the Washington Post reports.

In Nucleic Acids Research this week: the Aging Atlas database, a database of human metagenome-related metadata, and more.