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In a paper recently published online in advance in Cell, a team led by investigators at the Fox Chase Cancer Center in Philadelphia discuss "how unmethylated regions in mammalian genomes are protected from de novo methylation and whether an active demethylating activity is involved," and show that, in mice, "either knockout or catalytic inactivation of the DNA repair enzyme thymine DNA glycosylase leads to embryonic lethality." Overall, team reports that thymine DNA glycosylase, or TDG, "keeps C

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Bloomberg reports AstraZeneca may conduct another study of its candidate SARS-CoV-2 vaccine after dosing error.

Moderna is applying for an Emergency Use Authorization for its coronavirus vaccine, according to the New York Times.

The National Health Service is to conduct a trial of Grail's blood-based screening test for cancer.

In PLOS this week: somatic mutation patterns of glioblastomas among Lebanese patients, phenome-wide study using UK Biobank data, and more.