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In a paper recently published online in advance in Cell, a team led by investigators at the Fox Chase Cancer Center in Philadelphia discuss "how unmethylated regions in mammalian genomes are protected from de novo methylation and whether an active demethylating activity is involved," and show that, in mice, "either knockout or catalytic inactivation of the DNA repair enzyme thymine DNA glycosylase leads to embryonic lethality." Overall, team reports that thymine DNA glycosylase, or TDG, "keeps C

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The US Food and Drug Administration is to announce stricter standards for emergency authorizations of SARS-CoV-2 vaccines, reports the Washington Post.

The Associated Press reports Johnson & Johnson is starting a late-stage clinical trial of its candidate SARS-CoV-2 vaccine.

Bloomberg reports the budget of Operation Warp Speed is actually $18 billion, higher than the number typically cited.

In Genome Research this week: genomic analysis reveals role of super-spreaders in SARS-CoV-2, epigenetic drivers of cancer, and more.