In a recent Cancer Cell paper, researchers at St. Jude Children's Research Hospital and elsewhere report on their systematic deletions of a combination of tumor suppressor genes in a mouse model, which they found produced phenotypes with "striking similarities to subclasses of human diffuse astrocytoma." As a result of its investigations, the St. Jude-led team suggests that "there is a selective cooperativitiy among tumor suppressors" PTEN, TP53, and RB1 during glioma initiation.