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We Call It the Churchosome

George Church has made an artificial ribosome that successfully produces proteins, reports Technology Review. Church and his postdoc, Mike Jewitt, broke ribosomes from E. coli down to their component parts and then used enzymes to put all the proteins and RNA back together. They then used the reconstituted ribosome to produce luciferase. Next, they plan to make a ribosome that can reproduce itself, as well as make it more efficient and process molecules of different chirality. Tech Review adds that an artificial ribosome is a key step to creating artificial life.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.