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Way to Increase 'Disenchantment'

Big science is expensive and tends to promise a lot. But failure to deliver on those outsized promises — of new treatments, economic growth, and more — has led to a feeling of "disenchantment," writes Timothy Caulfield from the University of Alberta in The Globe and Mail. This, he adds, is one reason why funding agencies' focus on translational research "is so disappointing and frustrating." As a focus on translating research becomes tied to commercialization, hype will increase while public trust will diminish. "The best science is dispassionate, independent and objective. The promised pursuit of profits is one of the surest ways to erode these qualities," Caulfield says.

The Scan

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.

Machine Learning Improves Diagnostic Accuracy of Breast Cancer MRI, Study Shows

Combining machine learning with radiologists' interpretations further increased the diagnostic accuracy of MRIs for breast cancer, a Science Translational Medicine paper finds.

Genome Damage in Neurons Triggers Alzheimer's-Linked Inflammation

Neurons harboring increased DNA double-strand breaks activate microglia to lead to neuroinflammation like that seen in Alzheimer's disease, a new Science Advances study finds.

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.