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A Way Around It

Rootworms may be developing resistance to Monsanto's genetically engineered corn, which includes an insecticide to kill such pests, reports Bloomberg. A memo issued by the US Environmental Protection Agency says such resistance has emerged in four states in the Midwest, and that the ag-bio company's resistance-monitoring program is "inadequate." Monsanto tells Bloomberg that resistance to its Bt corn has not been confirmed, and that farmers with damaged crops should make changes, like rotating corn with soybeans or using Monsanto's SmartStax corn, which includes two types of Bt, to "stay ahead of this insect."

The memo "does throw a harsher light on the longer-term efficacy of the trait," Chris Shaw, an analyst at Monness Crespi Hardt & Co., tells Bloomberg. Shaw says Monsanto's development of SmartStax indicates that the company knows "it can't rely on a single gene to address farmers' problems," Bloomberg adds.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.