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Watch the Sausage Get Made

If you have some ideas on how to make the US National Science Foundation more open and transparent, head over to its OpenNSF site to submit them — just be sure to get there before March 19 when the comment period ends. "NSF's Open Government Web page will allow members of the public to submit ideas, comment on and vote for ideas proposed, and flag posts that are off-topic," says a press release. "In addition to welcoming general ideas and comments, NSF specifically seeks input regarding access to large data sets and collaborations that aim to facilitate transformative research." So far, ideas include "[requiring] all taxpayer funded research to be freely available" and that "NSF should live webcast all meetings."

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.