Harold Varmus is stepping down from his post as president of Memorial Sloan-Kettering, reports ScienceInsider. In his email to Sloan-Kettering staff, Varmus says that he had only planned to run the institute for about 10 years — he joined Sloan-Kettering in 2000 — and that “the institution would now benefit from a fresh approach.” Varmus also says that he’ll stay on until his replacement is found and that replacement will have big shoes to fill.