Case Western and UNC researchers used phage display and molecular modeling to identify a binding ligand with high affinity for CRIP1, or cysteine-rich intestinal protein 1, which is a novel biomarker for early detection of breast cancer. After modelling and synthesizing a new peptide, A1M, they found that A1M had a 10 to 28-fold improvement in binding affinity than the original sequence motifs from the phage display work. Their paper was published in PLoS Computational Biology last week.
Using 'Omics to Track Cancer Biomarkers
Aug 04, 2008