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Using 'Omics to Track Cancer Biomarkers

Case Western and UNC researchers used phage display and molecular modeling to identify a binding ligand with high affinity for CRIP1, or cysteine-rich intestinal protein 1, which is a novel biomarker for early detection of breast cancer. After modelling and synthesizing a new peptide, A1M, they found that A1M had a 10 to 28-fold improvement in binding affinity than the original sequence motifs from the phage display work. Their paper was published in PLoS Computational Biology last week.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.