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Using 'Omics to Track Cancer Biomarkers

Aug 04, 2008

Case Western and UNC researchers used phage display and molecular modeling to identify a binding ligand with high affinity for CRIP1, or cysteine-rich intestinal protein 1, which is a novel biomarker for early detection of breast cancer. After modelling and synthesizing a new peptide, A1M, they found that A1M had a 10 to 28-fold improvement in binding affinity than the original sequence motifs from the phage display work. Their paper was published in PLoS Computational Biology last week.

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The Tennessean reports that a state lab there can now run its own genome sequencing analyses of SARS-CoV-2 samples.

Sanction Violation Charges

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Nature Papers Examine Genomes of Centenarians, Transcription-Coupled DNA Repair

In Nature this week: analysis of centenarian genomes uncovers longevity-linked variants, and more.