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Using Monkeys to Study Huntington's Disease

In this Nature paper, researchers from Yerkes National Primate Research Center developed a transgenic model of Huntington's disease in the rhesus macaque by injecting rhesus oocytes with lentiviruses expressing exon 1 of the human HTT gene and viruses with the GFP gene. The transgenic monkeys exhibited symptoms, such as chorea and dystonia, similar to those of humans with HD. An accompanying News and Views is cautiously optimistic -- more research needs to be done -- but says this new disease model "opens the way to generating non-human primate models for other neurodegenerative diseases that are caused by single-gene mutations, such as familial forms of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis."

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.