Using Monkeys to Study Huntington's Disease

May 19, 2008

In this Nature paper, researchers from Yerkes National Primate Research Center developed a transgenic model of Huntington's disease in the rhesus macaque by injecting rhesus oocytes with lentiviruses expressing exon 1 of the human HTT gene and viruses with the GFP gene. The transgenic monkeys exhibited symptoms, such as chorea and dystonia, similar to those of humans with HD.

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