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Unregistered Trials

In the Journal of the American Medical Association, researchers report that most clinical trials are not properly registered. The researchers searched PubMed for recent clinical trials published in medical journals and high-impact specialty journals. Of those 323 trials, 45.5 percent were "adequately registered", meaning that they were "registered before the end of the trial, with the primary outcome clearly specified." Furthermore, the researchers found that, of those adequately registered trials, 31 percent showed discrepancies between the outcomes registered and the outcomes published. "We're asking people to tell readers honestly and transparently, 'What did you do, and what did you find?'" says paper author David Moher, from the Ottawa Hospital Research Institute in Canada in the New York Times.

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.