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Under Control

At Bitesize Bio, Shoba Anantha discusses how UNG can be useful in PCR analysis. Amplicons generated during PCR have dUTPs incorporated in them, Anantha notes, and UDG, the enzyme encoded in UNG, targets those dUTPs. If those amplicons are a source of contamination, using UDG before any other PCR reaction will target and make those sites abasic so that they will not "serve as good templates for Taq polymerase" while the original template will remain untouched. Anantha wonders whether UNG would be useful in real-time PCR and says that "false-positive result is often not from amplicon contamination, but due to primary sample DNA contamination" and says UNG won't be effective in that case.

The Scan

CDC Calls Delta "Variant of Concern"

CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern."

From FDA to Venture Capital

Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post.

Consent Questions

Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles.

Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes

In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.