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UK Report: Extend PhDs, Support Talented Researchers

Tim Wogan at ScienceInsider blogs about a report from the UK’s Council for Science and Technology, “A Vision for UK Research,” which suggests redesigning PhDs to last four years instead of three, with the first year or two “focused on entrepreneurial skills and management as well as research,” to round out a researcher’s education for potential careers in industry. Wogan writes that the report also suggests that research investment should be focused on retaining talented researchers who are able to work across several disciplines, rather than funding particular research areas.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.