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It's Ultra

Researchers at the University of Connecticut have developed a new method of multiple reaction monitoring mass-spec that can quantify targeted proteins. The team, led by Xudong Yao, calls it ultrathroughput MRM mass-spec. "It integrates the use of stable isotope dilution-multiple reaction monitoring mass spectrometry and peptide derivatization with inexpensive and commercial chemicals," the researchers write in their Analytical Chemistry study. Yao and his team say UMRM technology will have a "broad impact" on basic and applied biological and biomedical research. "Because of the flexibility in experimental design and reagent selection and the applicability of commercially available mass spectrometers, immediate adoption of the UMRM technology for targeted protein quantitation is expected," they write.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.