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Trying to Rise from the Dead

While Decode Genetics was able to find many links between genes and disease, "what it didn't find, however, was a business model that made sense," says this Newsweek article, and Decode went bankrupt in November. The company, however, is trying to rise from the ashes with an investment from Saga. The new CEO, Earl Collier is trying to turn Decode into a consulting company that would analyze researchers' sequencing data and "[give] it back in a nicely packaged way."

Daniel MacArthur points out that the article "gives the strong impression that the days of [deCODEme] are well and truly numbered" – Collier says that "if you want one, you'd better buy it now."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.