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True for E. coli, True for an Elephant?

Michael White blogs at Adaptive Complexity about looking at genomes from a network or mathematical approach. "Inferring network connections from genomic data may be great for putting together the wiring diagrams, but without directed experimentation on a given system, we can't say much about how a system is carrying out its function," he writes. "The biggest implication of this idea that there is no automatic or prescribed way of finding important functional features of systems is that our ability to generalize in systems biology may be limited."

The Scan

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.

Duke University Team Develops Programmable RNA Tool for Cell Editing

Researchers have developed an RNA-based editing tool that can target specific cells, as they describe in Nature.

Novel Gene Editing Approach for Treating Cystic Fibrosis

Researchers in Science Advances report on their development of a non-nuclease-based gene editing approach they hope to apply to treat cystic fibrosis.

Study Tracks Responses in Patients Pursuing Polygenic Risk Score Profiling

Using interviews, researchers in the European Journal of Human Genetics qualitatively assess individuals' motivations for, and experiences with, direct-to-consumer polygenic risk score testing.