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The Trial and Error Part is Depressing Enough

Jan 25, 2008

Researchers at Munich's Max Planck Institute for Psychiatry showed that mutations in the ABCB-1 gene affect how three widely used antidepressants work – or don't work, reports this Reuters article. Using mice genetically engineered to lack this gene, they found the gene and the protein blocked Celexa and Effexor but not Remeron. Since 30 percent of people don't respond to antidepressants, this could be the first step toward a pharmacogenomic test for efficacy.

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