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The Treacherous Waters of Translational Science

The US National Institutes of Health Director Francis Collins took the stage at TedMed — first with guitar in hand — to discuss the harzardous waters of translational medicine, reports The Wall Street Journal's Health Blog. Collins told the crowd that there is a gulf between basic and applied science, and that translational science isn't a bridge, but "more like a swimmer, a sailboat and a tugboat all attempting to cross the water. There are sharks and other obstacles in the water, causing the swimmer to die, the sailboat to capsize and the tugboat to run aground," the Health Blog reports. To move drug development forward, Collins said that pharmaceutical companies should look to their freezers to repurpose what's already there. The Health Blog adds that the main issue there is intellectual property, but says NIH is working with companies to draft an agreement to that end.

The Scan

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.

Machine Learning Improves Diagnostic Accuracy of Breast Cancer MRI, Study Shows

Combining machine learning with radiologists' interpretations further increased the diagnostic accuracy of MRIs for breast cancer, a Science Translational Medicine paper finds.

Genome Damage in Neurons Triggers Alzheimer's-Linked Inflammation

Neurons harboring increased DNA double-strand breaks activate microglia to lead to neuroinflammation like that seen in Alzheimer's disease, a new Science Advances study finds.

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.