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The Joy of a New Toy

Cancer Research UK's James Hadfield has been putting his lab's new HiSeq through its paces. The machine passed its validation run "with flying colours," Hadfield says on the SeqAnswers message board. "The validation run was a pair of PE flowcells with PhiX at 36bp read lengths. We obtained 51.5 and 56.0Gb of data from the flowcells which extrapolates to just over 300Gb from the run at PE100bp," he says, adding that he was so happy to get such a boost over 200Gb that he's pretty much sold on the HiSeq. The speed of data generation combined with the machine's ability to do two flowcells per instrument is going to make the HiSeq "indispensable," Hadfield says. With so much data being generated, however, collaboration with other labs is going to be key in analyzing it all, he adds.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.