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Touch-Down Tips

At Bitesize Bio, Shoba Anantha gives some tips on using touch-down PCR. She says this "very useful technique for improving PCR amplification specificity is trickier that it might seem at first." To reduce non-specific priming, she suggests keeping the reactions cold until it's time for thermal cycling and then she says that a hot-start is the best way to go. She also suggests limiting the number of cycles. "Too many cycles will lead to appearance of non-specific bands in the gel," Anantha writes.

The Scan

CDC Calls Delta "Variant of Concern"

CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern."

From FDA to Venture Capital

Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post.

Consent Questions

Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles.

Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes

In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.