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Topics for Further Research

Alex Palazzo rounds up some new papers on transcription and he says this recent research is showing that crosstalk between RNA polymerase and the organization of chromatin is widespread in the genome. Now, he says, the questions are:

1) how does the RNA degradation machinery "know" which transcript is the nc-RNA byproduct of this cross-talk and thus a substrate for degradation
2) how do the splicing and RNA nuclear export machineries "know" which transcripts are the real thing! We have pretty good evidence that these filters work very well in eukaryotes and there is a lot of genetic evidence that the RNA degradation machinery and the histone modification machinery communicate somehow to the proteins involved in mRNA nuclear export. This RNA filtering process is one of the main differences between euks and proks. But that filter is looking more and more mysterious.

 

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.