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Three Times the Charm?

A May 2010 Nature paper from the University of Chicago's Lina Chen and colleagues that reported that CD95 works to promote tumor growth has now been corrected three times, according to Ivan Oransky at Retraction Watch.

The first correction, issued online in March 2011, noted that an experimental error due to antibody cross-reactions affected their western blot analysis and that, after fixing the error, the result from that aspect of the study was no longer statistically significant. The second correction amended the first correction, saying the first letter contained the wrong panels.

Last week's correction says that the original article also included an incorrect actin blot and that some western blog data, which had been included as supplementary data, "were either misinterpreted or raw data could not be located." The researchers write that they repeated the experiment and were able to confirm their prior results. "All the conclusions of the original Letter are intact except for the data for the original Fig. 4f and g on the phosphorylation level of c-Jun and JNK in the livers of CD95-deficient mice, which have been corrected in two previous Corrigenda," the authors write. They add that first author Chen declined to sign the corrigenda.

The Scan

Wolf Howl Responses Offer Look at Vocal Behavior-Related Selection in Dogs

In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.