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Three for the Headache

Researchers at Harvard Medical School have uncovered three susceptibility loci associated with migraine. As they report in Nature Genetics, the researchers conducted a genome-wide association study of 5,122 people with a history of migraine and 18,108 without. Three SNPs, rs2651899 in PRDM16, rs10166942 in TRPM8, and rs11172113 in LRP1, were among the top associations with migraine, and were also found to be significant in three replication cohorts and in a meta-analysis of the discovery and replication cohorts, the authors report. As Agence-France Presse points out, the variants in PRDM16 and TRPM8 were found to be specific to migraine versus non-migraine headaches and the TRPM8 variant was specific to migraine in women. "While migraine remains incompletely understood and its underlying causes difficult to pin down, identifying these three genetic variants helps shed light on the biological roots for this common and debilitating condition," said lead author Daniel Chasman in a statement. His colleague Markus Schürks tells AFP that "inheritance of any of the genetic variants alters migraine risk by about 10 to 15 percent."

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.