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Though It Burns Your Mouth

Capsaicin, that spicy component of red peppers, might be useful in treating obesity. Korean researchers report in the Journal of Proteome Research how they fed one group of rats regular food along with saline, another received a high-fat diet and saline, while a third group of rats ate a high-fat diet with capsaicin diluted in saline to study the effect of capsaicin on weight gain. The rats who received capsaicin weighed about 8 percent less than the rats in the high-fat group that received only saline. Through proteomic analysis, the researchers show that capsaicin affects the regulation of about 20 proteins, many of which are involved in lipid metabolism and redox regulation. "Capsaicin," the researchers write, "may be a useful phytochemical for attenuation of obesity."

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.