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There's a Proteome We Didn't Expect

University of Washington researchers used a proteomics approach to characterize Drosophila seminal fluid that is transferred to the female fly. These proteins fill a variety of roles, such as aiding in sperm capacitation and fertilization. Using mass spectrometry, the researchers confirmed predicted seminal fluid proteins and identified new ones, including two new classes of proteins, and also estimated the relative abundance of the proteins. "Our experiments illustrate the power of combining proteomics with evolutionary biology to address fundamental questions about reproduction," the authors write.

The Scan

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.

DNA Storage Method Taps Into Gene Editing Technology

With a dual-plasmid system informed by gene editing, researchers re-wrote DNA sequences in E. coli to store Charles Dickens prose over hundreds of generations, as they recount in Science Advances.

Researchers Model Microbiome Dynamics in Effort to Understand Chronic Human Conditions

Investigators demonstrate in PLOS Computational Biology a computational method for following microbiome dynamics in the absence of longitudinally collected samples.

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.