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There's Now a Cream for That

Harvard's Judy Lieberman and her colleagues report on a topical RNAi-based treatment to prevent herpes infections. In their Cell Host & Microbe paper, they describe how they used a combination of siRNAs targeting viral and host genes to prevent HSV-2 transmission in mice. "One of the attractive features of the compound we developed is that it creates in the tissue a state that's resistant to infection, even if applied up to a week before sexual exposure. This aspect has a real practicality to it," Lieberman says.