Making RNAi work in therapeutic application is tricky, and here, Derek Lowe reports on a paper published in Nature last week that does a good job demonstrating just how much researchers don't know. They used RNAi to knock down VEGF, whose overactivation leads to macular degeneration.

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British Nobel laureates and Fields Medal winners warn that a 'hard' Brexit could harm science across the UK, the Guardian reports.

Vox reports on inequities in genetic research and efforts to address them.

The New York Times reports that Arizona State University's Lawrence Krauss is retiring following allegations of sexual misconduct.

In PNAS this week: de novo NUS1 mutations linked to Parkinson's disease risk, candidate hepatocellular carcinoma drivers, and more.