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There It Goes

The 2007 Journal of Clinical Oncology paper from Duke University's Anil Potti and his colleagues on pharmacogenomic strategies to treat people with advanced non–small-cell lung cancer has been retracted, reports Ivan Oransky at Retraction Watch. In the retraction, the article authors write that they "wish to retract this article because they have been unable to reproduce the experiments." Oransky notes that it is the journal's policy to have each author agree to the retraction and its wording and reports that Potti agreed to the retraction. Potti has also falsely said that he is a Rhodes Scholar and Oransky says that Potti "may have also faked an analysis of how breast cancer responds to chemotherapy."

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.