In a series of blog posts at Bits of DNA, computational biologist Lior Pachter criticizes a pair of papers appearing in Nature Biotechnology over the summer presenting methods to interrogate biological networks. Pachter in particular has harsh words for the Massachusetts Institute of Technology's Manolis Kellis. Pachter accuses Kellis's recent paper of being "dishonest and fraudulent." Kellis, in turn, says the accusations are "defamatory, baseless, misleading, and factually incorrect." A bit of a back-and-forth ensues.