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Teen Tackles Commercial Liquid-Handling Costs

Popular Science last month named 13-year-old Gabriel See one of the top 10 high-school inventors in the US, despite the fact that he's technically attending junior high, The Seattle Times' Katherine Long says. With "occasional help" from the University of Washington's Herbert Sauro, See "built a prototype model of a robot that could disperse small amounts of fluid into a plate of 96 wells" in 2009, which earned his team a silver medal at that year's iGEM synthetic biology competition. He was 11 years old at the time. Popular Science says that although "See still has to learn to drive and to go to prom … he's already hoping to study computational biology at MIT."

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.