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Discovering Biology in a Digital World's Sandra Porter says the coolest thing to do with next-gen sequencing is to look at transcriptomes. If you are new to dealing with next-gen sequencing data, take a look at her post to see how she handles sequence data from NCBI, aligning the reads, and comparing the different mouse and human isoforms of a gene of interest.

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The US Centers for Disease Control and Prevention has identified a small group of breakthrough COVID-19 cases, the Wall Street Journal reports.

Vox and Nature discuss the importance of preparing for the next pandemic.

The New York Times reports that the US Department of Defense is to use genetic genealogy approaches to identify the remains of unknown soldiers.

In Nature this week: comparison of five circulating tumor DNA assays, resequencing analysis of lettuce gives insight into its domestication, and more.