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Taz Genome vs. DFTD

Australia's ABC News reports that investigators at the Wellcome Trust Sanger Institute and their colleagues at Illumina have completed a draft sequence of the Tasmanian devil genome. According to Illumina, "the reference Tasmanian devil genome — approximately the same size as the human genome — was sequenced in eight days in one run … generating more than 80-fold genome coverage." The team suggests that their work will have implications for the study of devil facial tumor disease. The draft sequence will "open the door for new research to pick out those specific mutations that drive the cancer and will lay the foundation for ongoing work to trace the spread of disease and inform the development of preclinical tests, conservation strategies, and disease therapies," according to a Wellcome Trust Sanger Institute statement. Elizabeth Murchison, the project's PI, tells ABC News that "this gene map will help us to assess the diversity ... in the wild in order to help us design conservation efforts which will hopefully help us protect the devils."

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.