Researchers from the German Cancer Research Center are looking into which genes are responsible for the survival of cancer cells, according to a press release posted at ScienceBlog. The team found that the cells rely on the tension among specific protein fibers to multiply, and are hoping to develop anticancer drugs that specifically target these proteins. The idea is that once the proteins are switched off, the cancer cells will die, according to the release. Tumor cells survive — in spite of forming extra centrosomes — by assembling centrosomal clusters. Two clusters per cell are formed and a functioning bipolar spindle forms between them. The researchers in Germany investigated which genes enable the cells to form centrosome clusters and found that for the aggregation to work, the spindle fibers must be under tension, according to the ScienceBlog post. The team is now investigating which genes form the proteins responsible for keeping the fibers taut, and the best way to silence them.
Taking Out Cancer's Survival Tactic
Jun 01, 2010