Skip to main content
Premium Trial:

Request an Annual Quote

Taking It High-Throughput

The University of Indiana's Howard Edenberg and Yunlong Liu discuss methods for high-throughput genotyping in the November issue of Cold Spring Harbor Protocols. Their article is excerpted from the Genetics of Complex Human Diseases laboratory manual and, in it, they discuss candidate gene approaches, linkage studies, GWAS, and their follow-up studies. "High-throughput genotyping technology has enabled GWAS that have great promise for identifying genes that contribute to complex diseases and phenotypes and for large-scale follow-up of the top candidate genes from such studies," the authors write.

"Instead of focusing only on one or a few coding variants in a small sample of individuals, the ability to accurately and efficiently genotype many individuals and to cover more of the variation within individual genes has resulted in genetic studies with greater statistical power," says David Crotty, in a blog post at Bench Marks pointing out the article.

The Scan

Missed Early Cases

A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports.

Limited Journal Editor Diversity

A survey finds low diversity among scientific and medical journal editors, according to The Scientist.

How Much of a Threat?

Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned.

PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs

In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.