The University of Indiana's Howard Edenberg and Yunlong Liu discuss methods for high-throughput genotyping in the November issue of Cold Spring Harbor Protocols. Their article is excerpted from the Genetics of Complex Human Diseases laboratory manual and, in it, they discuss candidate gene approaches, linkage studies, GWAS, and their follow-up studies. "High-throughput genotyping technology has enabled GWAS that have great promise for identifying genes that contribute to complex diseases and phenotypes and for large-scale follow-up of the top candidate genes from such studies," the authors write.
"Instead of focusing only on one or a few coding variants in a small sample of individuals, the ability to accurately and efficiently genotype many individuals and to cover more of the variation within individual genes has resulted in genetic studies with greater statistical power," says David Crotty, in a blog post at Bench Marks pointing out the article.