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Taking It High-Throughput

The University of Indiana's Howard Edenberg and Yunlong Liu discuss methods for high-throughput genotyping in the November issue of Cold Spring Harbor Protocols. Their article is excerpted from the Genetics of Complex Human Diseases laboratory manual and, in it, they discuss candidate gene approaches, linkage studies, GWAS, and their follow-up studies. "High-throughput genotyping technology has enabled GWAS that have great promise for identifying genes that contribute to complex diseases and phenotypes and for large-scale follow-up of the top candidate genes from such studies," the authors write.

"Instead of focusing only on one or a few coding variants in a small sample of individuals, the ability to accurately and efficiently genotype many individuals and to cover more of the variation within individual genes has resulted in genetic studies with greater statistical power," says David Crotty, in a blog post at Bench Marks pointing out the article.

The Scan

Pig Organ Transplants Considered

The Wall Street Journal reports that the US Food and Drug Administration may soon allow clinical trials that involve transplanting pig organs into humans.

'Poo-Bank' Proposal

Harvard Medical School researchers suggest people should bank stool samples when they are young to transplant when they later develop age-related diseases.

Spurred to Develop Again

New Scientist reports that researchers may have uncovered why about 60 percent of in vitro fertilization embryos stop developing.

Science Papers Examine Breast Milk Cell Populations, Cerebral Cortex Cellular Diversity, Micronesia Population History

In Science this week: unique cell populations found within breast milk, 100 transcriptionally distinct cell populations uncovered in the cerebral cortex, and more.