Skip to main content
Premium Trial:

Request an Annual Quote

Removing the Guesswork

A paper published this week in PNAS from scientists at the Broad Institute looks at how to better identify the proteins to which small molecules and drugs bind to effect their mechanism of action. The group used a combination of quantitative proteomics, or SILAC, and affinity enrichment to find these proteins in an "unbiased, robust and comprehensive" way. Particularly, they detail applying the method to identifying targets of kinase inhibitors and immunophilin binders.

The Scan

Boosters Chasing Variants

The New York Times reports that an FDA advisory panel is to weigh updated booster vaccines for COVID-19.

Not Yet

The World Health Organization says monkeypox is not yet a global emergency, the Washington Post reports.

More Proposed for Federal Research

Science reports that US House of Representatives panels are seeking to increase federal research funding.

PLOS Papers on Breast Cancer Metastasis, Left-Sided Cardiac Defects, SARS-CoV-2 Monitoring

In PLOS this week: link between breast cancer metastasis and CLIC4, sequencing analysis of left-sided cardiac defects, and more.