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Removing the Guesswork

A paper published this week in PNAS from scientists at the Broad Institute looks at how to better identify the proteins to which small molecules and drugs bind to effect their mechanism of action. The group used a combination of quantitative proteomics, or SILAC, and affinity enrichment to find these proteins in an "unbiased, robust and comprehensive" way. Particularly, they detail applying the method to identifying targets of kinase inhibitors and immunophilin binders.

The Scan

CDC Calls Delta "Variant of Concern"

CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern."

From FDA to Venture Capital

Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post.

Consent Questions

Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles.

Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes

In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.