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Systems Biology, a 'Radioactive' Term

Has “systems biology” become just another term for “genomics”? asks Adaptive Complexity’s Michael White. That conflation of terms “has made the term systems biology radioactive in certain segments of the biomedical community. Systems biology has become the latest buzz-word, instead of an emerging discipline focused on new questions that were difficult to study 20 years ago,” he writes. White suggests that a new term, such as “biological dynamics”, could help set the field apart from genomics.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.