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Systems Biology in Flight

The Federal Aviation Administration is using systems biology tools to improve air safety, wrote two FAA members in a recent issue of the ISB Newsletter. The authors, Dennis Burian and Doris Kupfer, had attended a course on systems biology at the Institute for Systems Biology and wrote that the functional genomics team at the FAA would be using systems biology approaches to find biomarkers for "physiological impairment in crewmembers" such as fatigue and hypoxia. When found, the biomarkers would then become part of a blood-based microfluidic assay.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.