The US biomedical research system has "systemic flaws," write four prominent researchers in an editorial in the Proceedings of the National Academy of Sciences this week. They argue that an erroneous assumption that biomedical science would continue its rapid growth has led to a system plagued by hypercompetition that produces too many trainees contending for resources and encourages investigators to stick to well-worn research paths.

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In PLOS this week: phylogenetic study of hepatitis E viruses in Swedish moose, recombination sites in the honeybee genome, and more.

Differences in DNA methylation could be used to distinguish between DNA samples obtained from identical twins, researchers say.

A retrovirus that's been integrated into the human genome appears to have a role in embryonic development, researchers report.

A report from MIT identifies areas of scientific research where declining research support is hindering needed advances.