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Suprise Findings for Inbred Populations

Scientists have used microarrays to look at the broad genetic changes that accompany reproductive declines in inbred populations. Their study, published in Conservation Biology, is the first to look at genome-wide gene expression differences in inbred populations, small populations of closely related plants or animals that are likely to suffer from low reproductive success. Using six lines of fruit flies that had been inbred, they found that "significant amount of inbreeding depression is due to a few key genes that affect the expression of other genes," says University of Illinois at Urbana-Champaign's Ken Paige at Medical News Today. Of the 46 differentially expressed genes, those most important were involved in metabolism, stress, and defense. This is a surprising finding, Paige says, "because we think of inbreeding as a random process."

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.