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In Sum, We Found Nothing, But It's What We Wanted

A group of German researchers led by Pawel Smialowski and Philipp Pagel created a database, called the Negatome, of protein interactions that are unlikely to occur. As the report in Nucleic Acids Research, they scoured the literature for evidence against physical interactions of proteins and also analyzed protein complexes deposited in the Protein Data Bank to come up with their database, which may be found here. They report on 1,892 non-interacting proteins and predict a further 979 non-interacting domain pairs.
"The negatome is well on the way to become a 'gold-standard' dataset for training predictors of protein–protein interaction, thus proving that negative results are still results," adds Dr Jim at Mental Indigestion.

Just watch out for Jonathan Eisen's Worst New Omics Award.

The Scan

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.

Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets

Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.