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In Sum, We Found Nothing, But It's What We Wanted

A group of German researchers led by Pawel Smialowski and Philipp Pagel created a database, called the Negatome, of protein interactions that are unlikely to occur. As the report in Nucleic Acids Research, they scoured the literature for evidence against physical interactions of proteins and also analyzed protein complexes deposited in the Protein Data Bank to come up with their database, which may be found here. They report on 1,892 non-interacting proteins and predict a further 979 non-interacting domain pairs.
"The negatome is well on the way to become a 'gold-standard' dataset for training predictors of protein–protein interaction, thus proving that negative results are still results," adds Dr Jim at Mental Indigestion.

Just watch out for Jonathan Eisen's Worst New Omics Award.

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.