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Epigenetics of Autism

Apr 09, 2010

A paper published in the FASEB Journal this week relays the results of a large-scale CpG island microarray methylation profiling "analysis of lymphoblastoid cell lines derived from monozygotic twins discordant for diagnosis of autism and their nonautistic siblings." AnhThu Nguyen and colleagues found two candidate genes for autism — they confirmed BCL-2 as a candidate using bisulfite sequencing, and discovered the retinoic acid-related orphan receptor alpha, or RORA, as a novel candidate using methylat

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