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A Link Between Breast Cancer and Estrogen

A new study in Cancer Research from Loyola University Chicago Stritch School of Medicine researchers is providing new clues as to how estrogen fuels many breast cancers. The researchers have found that the hormone inhibits the MLK3 protein that causes normal cell death. When the protein is blocked, cancer cells can grow uncontrolled, and can be resistant to chemotherapy. The researchers found that in estrogen-positive or progesterone-positive cancer cells, MLK3 activity was reduced. This could give medicine new ways the fight the deadly disease as about 60 percent of all breast cancers are estrogen-positive or progesterone-positive.

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.