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Strides for Schizophrenia Research

Thomas Insel, director of the National Institute of Mental Health, says that genomics has been an "area of unambiguous progress" for schizophrenia research during the last few years. At his blog, Insel highlights how genomics researchers have identified several genes associated with schizophrenia risk, which are "not the usual suspects," he says. Rare variants associated with the disorder may also have a considerable impact on future research, he suggests. "These rare events may explain only a small fraction of cases, but as with hypertension and cancer, even rare mutations that cause disease can yield important clues to the pathophysiology underlying more common forms of disease," Insel says. Though throughout the "past century, schizophrenia has been defined by psychosis," he credits genomics researchers for reinforcing the "importance of reconceptualizing schizophrenia as a neurodevelopmental disorder."

The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.