Scientists try to answer questions for a living, says Benchfly's Alan Marnett. But certain questions asked by family and friends may "trigger a primal response" after being asked over and over again, he adds. To avoid any "future explosions," it's best to identify these questions early on and warn people not to ask them. The most annoying question to be asked, according to Marnett's poll, is: "When are you going to graduate?" It is followed closely by: "Explain to me what you do, again?"