Skip to main content
Premium Trial:

Request an Annual Quote

The Elusive Protein, Found

Three groups of researchers have found the BRCA2 protein that is believed to contribute to inherited cases of breast and ovarian cancer, reports New Scientist's Jessica Hamzelou. It's been known that mutations in the BRCA2 gene can cause DNA damage leading to cancer, but until now, the protein has been difficult to isolate. A team at UC Davis led by Stephen Kowalczykowski isolated the protein by inserting the gene into a human virus and infecting human embryonic kidney cells, which then expressed the protein, Hamzelou says. They then found that about six RAD-51 proteins (which also repair DNA damage) bind to BRCA2. Another UC Davis team led by Wolf-Dietrich Heyer expressed the BRCA2 gene in yeast, and came to same conclusions about its interactions with RAD-51, Hamzelou reports. In addition, a team led by Stephen West at Cancer Research UK found that BRCA2 takes RAD-51 where it needs to go to repair DNA damage, she adds, which could explain why BRCA2 mutations lead to more DNA damage.

The Scan

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.

DNA Biobank Developed for French Kidney Donors, Recipients

The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France.

Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut

By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site.

Study Reveals New Details About Genetics of Major Cause of Female Infertility

Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.