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Staying Well

Not everybody with a genetic variant linked to a disease comes down with that condition, something that Resilience Project researchers are beginning to study.

Stephen Friend and his colleagues are looking for volunteers to donate their DNA so that they can track down people who had a healthy childhood but who harbor variants that should've made them sick.

"We anticipate that once we identify these 'resilient' individuals, further study will help reveal key insights into the biology of these diseases, and how they have been protected via genetic or environmental factors to avoid getting ill," the project website says.

Juhan Sonin, a volunteer from Boston, tells the New Scientist that he's participating in the study to help bring about a time when disease can be treated before people know they are sick.

"[B]y diving deeper into genetics in this way, we stand a chance of fighting disease before we even have symptoms," Sonin says.

When the New Scientist asks how he thinks he'd feel if he turns out to have one of those disease-causing mutations, but also another factor that prevented him from getting ill, Sonin says, "It would be simultaneously hair-raising and fabulous. While I would want to know all the details of how that could impact my children, the promise of being part of unraveling and solving a serious disease is splendid."

The Scan

Booster for At-Risk

The New York Times reports that the US Food and Drug Administration has authorized a third dose of the Pfizer-BioNTech SARS-CoV-2 vaccine for people over 65 or at increased risk.

Preprints OK to Mention Again

Nature News reports the Australian Research Council has changed its new policy and now allows preprints to be cited in grant applications.

Hundreds of Millions More to Share

The US plans to purchase and donate 500 million additional SARS-CoV-2 vaccine doses, according to the Washington Post.

Nature Papers Examine Molecular Program Differences Influencing Neural Cells, Population History of Polynesia

In Nature this week: changes in molecular program during embryonic development leads to different neural cell types, and more.