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So That's ChIP-Seq

At Bitesize Bio, James Hadfield gives an introduction to ChIP-seq for the uninitiated. Chromatin immunoprecipitation allows researchers to determine where protein-binding sites are located on DNA, and researchers coupled that approach to arrays, making ChIP-chip analyses. But, as Hadfield notes, "while this was a revolutionary approach, the technique is limited by the array technologies used." And so, chromatin immunoprecipitation was joined up with next-gen sequencing technologies. "ChIP-seq has been widely adopted since it was first reported in 2007. In fact, it has almost totally supplanted ChIP-chip, since it allows genome-wide analysis and does not have the limitations [of ChIP-chip]," he adds.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.