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So That's ChIP-Seq

At Bitesize Bio, James Hadfield gives an introduction to ChIP-seq for the uninitiated. Chromatin immunoprecipitation allows researchers to determine where protein-binding sites are located on DNA, and researchers coupled that approach to arrays, making ChIP-chip analyses. But, as Hadfield notes, "while this was a revolutionary approach, the technique is limited by the array technologies used." And so, chromatin immunoprecipitation was joined up with next-gen sequencing technologies. "ChIP-seq has been widely adopted since it was first reported in 2007. In fact, it has almost totally supplanted ChIP-chip, since it allows genome-wide analysis and does not have the limitations [of ChIP-chip]," he adds.

The Scan

And Back

The New York Times reports that missing SARS-CoV-2 genome sequences are back in a different database.

Lacks Family Hires Attorney

A lawyer for the family of Henrietta Lacks plans to seek compensation from pharmaceutical companies that have used her cancer cells in product development, the Baltimore Sun reports.

For the Unknown

The Associated Press reports that family members are calling on the US military to use new DNA analysis techniques to identify unknown sailors and Marines who were on the USS Arizona.

PLOS Papers on Congenital Heart Disease, COVID-19 Infection Host MicroRNAs, Multiple Malformation Mutations

In PLOS this week: new genes linked to congenital heart disease, microRNAs with altered expression in COVID-19, and more.