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So Simple, But so Easy to Mess Up

There are many different ways to mess up an experiment, and Emily Crow at Bitesize Bio gives five ways "to destroy your agarose gel." Her favorite ways to do so include using water instead of TAE or TBE buffer, not adding the ethidium bromide, and just dropping the nicely made gel on the floor, among others. "Pouring and running an agarose gel is a simple and routine procedure that you probably learned soon after joining your first lab. A procedure that couldn't possibly go wrong," Crow says."Or so you'd think. In fact, there are a surprising number of ways to destroy your agarose gel."

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.